Dimethylamine → HCID 19767687, compound

HRID 1590633Notes

Reaction equation

HRID 1590633 reaction equation
Cl[C:2]1[C:3]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:4]=2[N:5]=[C:6]([N:8]([CH3:10])[CH3:9])[N:7]=1.[CH3:22][NH:23][CH3:24]>C(O)C>[CH3:9][N:8]([C:6]1[N:7]=[C:2]([N:23]([CH3:24])[CH3:22])[C:3]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:4]=2[N:5]=1)[CH3:10]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19767702HCID 19767702, compound

Product 1

HCID 19767687HCID 19767687, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner analogous to that described in Example 12, 1.95 g (6.36 mmol) of 7-chloro-5-(N,N-dimethylamino)-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine are dissolved in 200 ml of warm ethanol, 7 ml of aqueous dimethylamine solution (40%) are added and the mixture is left to stand for 30 minutes. After dilution with 200 ml of water, the product is filtered off with suction and recrystallised from ethanol. In this manner 5,7-bis(N,N-dimethylamino)-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine having a melting point of 123°-125° is obtained.

Workup

  1. waitthe mixture is left
  2. filtrationAfter dilution with 200 ml of water, the product is filtered off with suction
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-163e417fbef24e3180e3be45e9d52f4d
Source dataset
uspto-grants-1993_04
Patent number
US05204353

Reaction notes

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