Dimethylamine → HCID 19767687, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 12, 1.95 g (6.36 mmol) of 7-chloro-5-(N,N-dimethylamino)-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine are dissolved in 200 ml of warm ethanol, 7 ml of aqueous dimethylamine solution (40%) are added and the mixture is left to stand for 30 minutes. After dilution with 200 ml of water, the product is filtered off with suction and recrystallised from ethanol. In this manner 5,7-bis(N,N-dimethylamino)-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine having a melting point of 123°-125° is obtained.

Provenance & Evidence