1,3-Dibromopropane → 5-(3-Bromopropoxy)quinoline

HRID 1590645Notes

Reaction equation

HRID 1590645 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Br:12][CH2:13][CH2:14][CH2:15]Br.CC([O-])(C)C.[K+]>>[Br:12][CH2:13][CH2:14][CH2:15][O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

4

Reactant 3

HCID 80011,3-DibromopropaneHCID 23665647Potassium tert-butoxideHCID 135441757Quinolin-5-ol

Product 1

HCID 200790485-(3-Bromopropoxy)quinolineYield 35.5%

Procedure

Following the same procedure as in Example 1-(a), reaction and treatment were carried out using 1.0 g of 5-hyroxyquinoline, 2.1 g of 1,3-dibromopropane and 0.78 g of t-BuOK as a base, in order to obtain 0.65 g of 5-(3-bromopropoxy)quinoline.

Sources & evidence

ORD record
ord-6a40c1e0eeb7411687ef38c44887948a
Source dataset
uspto-grants-1993_04
Patent number
US05204348

Reaction notes

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