Potassium Carbonate → HCID 20079018, compound

HRID 1590649Notes

Reaction equation

HRID 1590649 reaction equation
[C:1]([N:4]([CH2:15][CH:16]([O:37]C(=O)C)[CH2:17][N:18]1[CH2:23][CH2:22][N:21]([CH:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)[C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([N:4]([CH2:15][CH:16]([OH:37])[CH2:17][N:18]1[CH2:19][CH2:20][N:21]([CH:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:22][CH2:23]1)[C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 20079041HCID 20079041, compound

Product 1

HCID 20079018HCID 20079018, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

In a mixed solvent of 10 ml of methanol and 5 ml of water were dissolved 0.55 g of 5-[N-acetyl-(2-acetoxy-3-(4-diphenylmethylpiperazine-1-yl)propylamino)]quinoline and 0.5 g of potassium carbonate, and the liquid was allowed to stand at room temperature overnight. The liquid was extracted with methylene chloride, and the extract was then dried with anhydrous magnesium sulfate and was concentrated to obtain 0.5 g of the desired compound.

Workup

  1. extractionThe liquid was extracted with methylene chloride
  2. dry with materialthe extract was then dried with anhydrous magnesium sulfate
  3. concentrationwas concentrated

Sources & evidence

ORD record
ord-9eda26b492424804b86818e782403a48
Source dataset
uspto-grants-1993_04
Patent number
US05204348

Reaction notes

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