Triethylamine → HCID 10975521, compound

HRID 1590771Notes

Reaction equation

HRID 1590771 reaction equation
Cl.[NH2:2][CH2:3][C@@H:4]([C@H:8]([OH:10])[CH3:9])[C:5]([OH:7])=[O:6].C(N(CC)CC)C>C(#N)C>[NH2:2][CH2:3][C@@H:4]([C@H:8]([OH:10])[CH3:9])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 86744465(2S,3R)-2-aminomethyl-3-hydroxybutyric acid hydrochloride

Product 1

HCID 10975521HCID 10975521, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

6.14 g (36.22 mmol) of (2S,3R)-2-aminomethyl-3-hydroxybutyric acid hydrochloride was added with 150 ml of acetonitrile, and further added, while cooled in ice, with 5.05 ml (36.22 mmol) of triethylamine, then subjected to a vigorous stirring for 2 days at room temperature. Precipitated powdery crystals were collected, washed with 100 ml of acetonitrile and filtered to obtain 4.07 g of the title compound in crystals (yield: 84%).

Workup

  1. additionfurther added
  2. customPrecipitated powdery crystals were collected
  3. washwashed with 100 ml of acetonitrile
  4. filtrationfiltered

Sources & evidence

ORD record
ord-260f64a200f84c9d92fb25820024ebba
Source dataset
uspto-grants-1993_04
Patent number
US05204460

Reaction notes

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