Water → HCID 54180567, compound

HRID 1590816Notes

Reaction equation

HRID 1590816 reaction equation
O.C(OC([NH:12][C@@H:13]([C:17]([NH:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[C:21]=1[C:22]([OH:24])=[O:23])=[O:18])[CH:14]([CH3:16])[CH3:15])=O)C1C=CC=CC=1>[Pd].CO>[CH3:29][C:25]1[C:21]([C:22]([OH:24])=[O:23])=[C:20]([NH:19][C:17](=[O:18])[C@@H:13]([CH:14]([CH3:15])[CH3:16])[NH2:12])[CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 2

HCID 962WaterHCID 54068794HCID 54068794, compound

Product 1

HCID 54180567HCID 54180567, compoundYield 79.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10% Pd-C (70 mg) was added to a 1% water-containing methanol solution (30 ml) of 2-(N-benzyloxycarbonyl-D-valyl)amino-6-methylbenzoic acid (669 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for two hours. After the catalyst was filtered off, the filtrate was concentrated to obtain 6-methyl-2-(D-valylamino)benzoic acid (347 mg).

Workup

  1. filtrationAfter the catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-662fc53128ee4693a9ed7d1c7ff45a94
Source dataset
uspto-grants-1993_04
Patent number
US05204462

Reaction notes

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