反应详情

To 790 mg of 6-methoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline, was added 16 ml of 48% hydrobromic acid, and the mixture was heated under reflux for 3 hours under an argon stream. The reaction solution was cooled, and precipitates which separated out were collected by filtration, giving 630 mg of 6-hydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours under an argon stream
3. temperatureThe reaction solution was cooled
4. customprecipitates which
5. customseparated out
6. filtrationwere collected by filtration