1-Bromodecane → HCID 19768424, compound

HRID 1590848Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:10][N:9]=2)=[C:4]([F:23])[CH:3]=1.Br[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[CH2:25]([O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:10][N:9]=2)=[C:4]([F:23])[CH:3]=1)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

Participants

Reactant 2

HCID 81731-Bromodecane

HCID 135827542HCID 135827542, compound

Product 1

HCID 19768424HCID 19768424, compound

Procedure

2-(4-Hydroxy-2-fluorophenyl)-5-octyloxypyridine, which is alkylated with 1-bromodecane to produce 2-(4-n-decyloxy-2-fluorophenyl)-5-octyloxypyridine, is obtained analogously by reacting 4-benzyloxy-2-fluoroacetophenone with 2-octyloxytrimethinium perchlorate, ammonium acetate 5. and hydrogenating cleavage of the benzyl ether.

Sources & evidence

ORD record: ord-7b6372a5bad344789a0db0e8b92b72a3
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05204476

Reaction notes

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