反应详情

A mixture of diethyl n-butylmalonate (11.55 g, 53.4 mmol), 4-hydroxy-1-methoxy-2,2,6,6-tetramethylpiperidine (20.0 g, 107 mmol), lithium amide (120 mg), and xylene (100 ml) is distilled until the distillate reaches a constant temperature of 137° C. Xylene is evaporated and the residue is dissolved in heptane. Acetic acid is added and the resulting precipitate is filtered. The filtrate is concentrated to obtain 26.2 g (98% yield) of a light yellow oil.

1. distillationis distilled until the distillate
2. customa constant temperature of 137° C
3. customXylene is evaporated
4. dissolutionthe residue is dissolved in heptane
5. additionAcetic acid is added
6. filtrationthe resulting precipitate is filtered
7. concentrationThe filtrate is concentrated