Dimethyl Succinate → HCID 19768325, compound

HRID 1590948Notes

Reaction equation

HRID 1590948 reaction equation
[CH:1]1([O:7][N:8]2[C:13]([CH3:15])([CH3:14])[CH2:12][CH:11]([NH2:16])[CH2:10][C:9]2([CH3:18])[CH3:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:19]([O:27]C)(=O)[CH2:20][CH2:21][C:22]([O:24]C)=O.[CH3:29][O-:30].[Na+]>>[CH:1]1([O:7][N:8]2[C:9]([CH3:18])([CH3:17])[CH2:10][CH:11]([NH:16][C:22](=[O:24])[CH2:21][CH2:20][C:19]([NH:16][CH:11]3[CH2:10][C:9]([CH3:17])([CH3:18])[N:8]([O:30][CH:29]4[CH2:5][CH2:6][CH2:1][CH2:2][CH2:3]4)[C:13]([CH3:14])([CH3:15])[CH2:12]3)=[O:27])[CH2:12][C:13]2([CH3:14])[CH3:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 7820Dimethyl SuccinateHCID 10942334Sodium MethoxideHCID 222779844-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

Product 1

HCID 19768325HCID 19768325, compoundYield 252.3%

Procedure

A mixture of 1-cyclohexyloxy-4-amino-2,2,6,6-tetramethylpiperidine (2.65 g), dimethyl succinate (1.46 g) and sodium methoxide (50 mg) is heated at 180°-190° C. for 4 hours. The crude product is recrystallized from ethanol/water to afford 1.38 g of the title compound as a white solid, m.p. 230°-34° C.

Workup

  1. temperatureis heated at 180°-190° C. for 4 hours
  2. customThe crude product is recrystallized from ethanol/water

Sources & evidence

ORD record
ord-53a1246b20654b0a9723fd799fbbb279
Source dataset
uspto-grants-1993_04
Patent number
US05204473

Reaction notes

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