Butylamine → HCID 21182124, compound

HRID 1590949Notes

Reaction equation

HRID 1590949 reaction equation
[CH3:1][O:2][N:3]1[C:8]([CH3:10])([CH3:9])[CH2:7][C:6](=O)[CH2:5][C:4]1([CH3:13])[CH3:12].[CH2:14]([NH2:18])[CH2:15][CH2:16][CH3:17]>[Pt].CO>[CH3:1][O:2][N:3]1[C:8]([CH3:10])([CH3:9])[CH2:7][CH:6]([NH:18][CH2:14][CH2:15][CH2:16][CH3:17])[CH2:5][C:4]1([CH3:13])[CH3:12]

Participants

5

Reactant 2

HCID 8007ButylamineHCID 109761931-Methoxy-2,2,6,6-tetramethylpiperidin-4-one

Product 1

HCID 21182124HCID 21182124, compoundYield 80.2%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 10.1 g (54.5 mmol) of 1-methoxy-2,2,6,6-tetramethylpiperidin-4-one, 27.9 g (382 mmol) of n-butyl amine, 100 ml of methanol, and 1.0 g of 5% platinum on carbon is hydrogenated (50 psi, 25° C.) for 5 hours. The catalyst is removed by filtration. Evaporation of the filtrate gives an oil which is purified by fractional distillation to afford 10.6 g (80% yield) of the title compound, a colorless oil, b.p. 93°-100° C. (0.25 mm).

Workup

  1. custom(50 psi, 25° C.)
  2. customfor 5 hours
  3. customThe catalyst is removed by filtration
  4. customEvaporation of the filtrate
  5. customgives an oil which
  6. distillationis purified by fractional distillation

Sources & evidence

ORD record
ord-34943ea8865541918795fc484942e1ab
Source dataset
uspto-grants-1993_04
Patent number
US05204473

Reaction notes

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