Hydrazine hydrate (1:1) → HCID 15003896, compound

HRID 1590964Notes

Reaction equation

HRID 1590964 reaction equation
[NH:1]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:2][C:3]([NH:5][C@H:6]([C:16]([NH:18][C@H:19]([C:24]([NH:26][C@H:27]([C:32]([O:34]CC)=O)[CH2:28][CH:29]([CH3:31])[CH3:30])=[O:25])[CH2:20][C:21](=[O:23])[NH2:22])=[O:17])[CH2:7][O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:4].[NH2:44][NH2:45].O>CO>[NH:1]([C:37]([O:39][C:40]([CH3:42])([CH3:41])[CH3:43])=[O:38])[CH2:2][C:3]([NH:5][C@H:6]([C:16]([NH:18][C@H:19]([C:24]([NH:26][C@H:27]([C:32]([NH:44][NH2:45])=[O:34])[CH2:28][CH:29]([CH3:30])[CH3:31])=[O:25])[CH2:20][C:21](=[O:23])[NH2:22])=[O:17])[CH2:7][O:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15003895HCID 15003895, compound

Product 1

HCID 15003896HCID 15003896, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.80 Grams of Boc-Gly-Ser(Bzl)-Asn-Leu-OEt was dissolved in 30 ml of methanol. Thereto was added 2.25 ml of NH2NH2.H2O. The mixture was allowed to stand for 2 days at room temperature. The resulting precipitate was collected by filtration and washed with methanol to obtain 2.16 g (yield: 79.0%) of the above objective compound. Melting point: 221°-224° C.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with methanol

Sources & evidence

ORD record
ord-729ea4d8977d4bf5981bd6f307331542
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Reaction notes

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