HCID 15940120, compound → HCID 15940121, compound

HRID 1590972Notes

Reaction equation

HRID 1590972 reaction equation
[NH:1]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[C@H:2]([C:8]([NH:10][C@H:11]([C:23]([NH:25][C@H:26]([C:31]([O:33]CC1C=CC=CC=1)=[O:32])[CH2:27][CH:28]([CH3:30])[CH3:29])=[O:24])[CH2:12][CH2:13][C:14](=[O:22])[O:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].C(OCC)C.CCCCCC>C1COCC1.[C].[Pd]>[NH:1]([C:41]([O:43][C:44]([CH3:46])([CH3:45])[CH3:47])=[O:42])[C@H:2]([C:8]([NH:10][C@H:11]([C:23]([NH:25][C@H:26]([C:31]([OH:33])=[O:32])[CH2:27][CH:28]([CH3:30])[CH3:29])=[O:24])[CH2:12][CH2:13][C:14](=[O:22])[O:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6]

Participants

5

Reactant 2

HCID 15940120HCID 15940120, compoundHCID 21584099Diethylether hexane

Product 1

HCID 15940121HCID 15940121, compoundYield 98.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

21.0 Grams of Boc-Gln-Glu(OcHex)-Leu-OBzl was dissolved in 200 ml of THF, and the solution was subjected to catalytic reduction in the presence of 2.00 g of 5%-palladium-carbon as the catalyst. After the reduction was finished, the catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. To the residue thus obtained was added diethyl ether-n-hexane to crystallize to obtaine 17.86 g (yield: 98.5%) of the above-mentioned objective product.

Workup

  1. customthe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customTo the residue thus obtained
  4. customto crystallize

Sources & evidence

ORD record
ord-937701b36a614bf3b68afc59e2709af3
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Reaction notes

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