6-Bromo-1-(1-imidazolyl)-3,4-dihydronaphthalene → 5-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carbonitrile

HRID 1591077Notes

Reaction equation

HRID 1591077 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1)=[CH:7][CH2:6][CH2:5]2.[C:17]([Cu])#[N:18]>CN1CCCC1=O>[C:17]([C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1)=[CH:7][CH2:6][CH2:5]2)#[N:18]

Participants

4

Reactant 2

HCID 233653486-Bromo-1-(1-imidazolyl)-3,4-dihydronaphthaleneHCID 178418546HCID 178418546, compound

Product 1

HCID 98373925-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carbonitrile

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

6-bromo-1-(1-imidazolyl)-3,4-dihydronaphthalene (Example 6) is converted by reaction with CuCN in 1-methylpyrrolidone into the title compound, m.p. 152°-153°.

Sources & evidence

ORD record
ord-41bd64185ace4e7ba68e6b058b140210
Source dataset
uspto-grants-1993_04
Patent number
US05206256

Reaction notes

Loading…