反应详情

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-dicyanoimidazole (3.3 g, 0.01 mol) and potassium hydroxide (85%, 1.64 g, 0.025 mol) in ethanol (20 ml) and water (2 ml) was heated at reflux for 3.5 hours. After cooling the mixture was poured into water (100 ml) and acidified to pH1 by the addition of concentrated hydrochloric acid. The precipitated solid was filtered off and dried at 80° C. and 10 mm Hg to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide (0.6 g), m.p. 306°-308° C., as an off white solid.

1. temperaturewas heated
2. temperatureat reflux for 3.5 hours
3. temperatureAfter cooling the mixture
4. filtrationThe precipitated solid was filtered off
5. customdried at 80° C.