Acetic Anhydride → 1'-acetylspiro[2H-indene-2,4'-piperidine]-1(3H)-one

HRID 1591154Notes

Reaction equation

HRID 1591154 reaction equation
[O:1]=[C:2]1[C:10]2([CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:9][C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(Cl)Cl>[C:16]([N:13]1[CH2:14][CH2:15][C:10]2([CH2:9][C:8]3[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:2]2=[O:1])[CH2:11][CH2:12]1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19085830Spiro[indene-2,4'-piperidin]-1(3H)-one

Product 1

HCID 190454721'-acetylspiro[2H-indene-2,4'-piperidine]-1(3H)-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.13 g (5.6 mmoles) 1,3-dihydro-1-oxospiro[2H-indene-2,4'-piperidine] in 15 ml methylene chloride cooled to 0° C. was added 1.23 g (12.0 mmoles) acetic anhydride. The solution was stirred at 0° for 1 hour and the solvent was removed in vacuo to give crude 1'-acetylspiro[2H-indene-2,4'-piperidine]-1(3H)-one.

Workup

  1. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-9ae72c230f9f4b7db77a5e7643210d0f
Source dataset
uspto-grants-1993_04
Patent number
US05206240

Reaction notes

Loading…