HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1'-acetylspiro[2H-indene-2,4'-piperidine]-1(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Spiro[indene-2,4'-piperidin]-1(3H)-one | HCID 19085830 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1'-acetylspiro[2H-indene-2,4'-piperidine]-1(3H)-one | HCID 19045472 | — |
Reaction Steps
To a solution of 1.13 g (5.6 mmoles) 1,3-dihydro-1-oxospiro[2H-indene-2,4'-piperidine] in 15 ml methylene chloride cooled to 0° C. was added 1.23 g (12.0 mmoles) acetic anhydride. The solution was stirred at 0° for 1 hour and the solvent was removed in vacuo to give crude 1'-acetylspiro[2H-indene-2,4'-piperidine]-1(3H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206240 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-9ae72c230f9f4b7db77a5e7643210d0f |
| Source note | uspto-grants-1993_04 |