Hydrochloric Acid → 2-[4-(Aminomethyl)phenyl]ethan-1-ol

HRID 1591190Notes

Reaction equation

HRID 1591190 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([CH2:7][CH2:8][OH:9])=[CH:5][CH:4]=1)#[N:2].Cl>C(O)C.[Pd]>[OH:9][CH2:8][CH2:7][C:6]1[CH:10]=[CH:11][C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 28008154-(2-Hydroxyethyl)benzonitrile

Product 1

HCID 226014582-[4-(Aminomethyl)phenyl]ethan-1-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 0.74 g (0.005 mol) of p-cyanophenethyl alcohol in 50 ml of ethanol containing 10 ml of concentrated hydrochloric acid was hydrogenated at 30 psi using 0.1 g 5% Pd/C for 72 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure.

Workup

  1. customfor 72 hours
  2. customThe catalyst was removed by filtration
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0575f38d34cd444d949321fac434cb54
Source dataset
uspto-grants-1993_04
Patent number
US05206240

Reaction notes

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