反应详情

100 parts of anhydrous sodium acetate are introduced into 400 parts by volume of acetic anhydrice, 168 parts of 2-amino-3-cyano-4-ethoxythiophene are added and the mixture is refluxed for 4 hours. Thereafter, 800 parts of water are added dropwise to the hot mixture, the mixture is left to cool and the product is filtered off under suction, washed with water and dried to give 194 parts of 2-acetylamino-3-cyano-4-ethoxythiophene of melting point 242°-243° C. (from acetic acid).

1. additionare added
2. temperaturethe mixture is refluxed for 4 hours
3. waitthe mixture is left
4. temperatureto cool
5. filtrationthe product is filtered off under suction
6. washwashed with water
7. customdried