HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → N-(3-Cyano-4-ethoxythiophen-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester | HCID 613145 | — |
| Reactant | 2-Amino-4-ethoxythiophene-3-carbonitrile | HCID 13742380 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(3-Cyano-4-ethoxythiophen-2-yl)acetamide | HCID 13742383 | — |
Reaction Steps
100 parts of anhydrous sodium acetate are introduced into 400 parts by volume of acetic anhydrice, 168 parts of 2-amino-3-cyano-4-ethoxythiophene are added and the mixture is refluxed for 4 hours. Thereafter, 800 parts of water are added dropwise to the hot mixture, the mixture is left to cool and the product is filtered off under suction, washed with water and dried to give 194 parts of 2-acetylamino-3-cyano-4-ethoxythiophene of melting point 242°-243° C. (from acetic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206375 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-4896cfd6cedd464f922884e9b88f535a |
| Source note | uspto-grants-1993_04 |