Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 1591327Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

Product 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-oneYield 73.6%

Procedure

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

Sources & evidence

ORD record: ord-fb654f5d6f7d43dc8a492bf02a39af0c
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05206364

Reaction notes

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