4-(((Tert-butoxy)carbonyl)amino)butanoic acid → 4-t-Butoxycarbonylamino-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide

Participants

Reaction Steps

Prepared from 3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step A) and 4-(t-butoxycarbonylamino)butyric acid by the procedure described in Example 25, Step A. 1H NMR (200 MHz, CDCl3): 1.42 (s,9H), 1.7-2.1 (m,3H), 2.24 (t,5 Hz,2H), 2.58-3.29 (m,5H), 4.57 (m,1H), 4.86 (br s,1H), 7.0-7.3 (m,4H), 8.32 (s,1H). FAB-MS: calculated for C19H27N3O4 361; found 362 (M+H,60%).

Provenance & Evidence