3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 19025533, compound

HRID 1591448Notes

Reaction equation

HRID 1591448 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][CH:17]1[CH2:23][CH2:22][C:21]2[C:24]([F:28])=[CH:25][CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:29]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[C:24]([F:28])=[CH:25][CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:29])=[O:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 103760463-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acidHCID 197661863-Amino-6-fluoro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Product 1

HCID 19025533HCID 19025533, compound

Procedure

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and the amine obtained in Step F by the procedure described in Example 1, Step F. 1H NMR (300 MHz, CDCl3): 1.36 (s,6H), 1.43 (s,9H), 1.91 (m,1H), 2.4-2.8 (m,3H), 3.18 (m,2H), 4.54 (m,1H), 5.18 (br s,1H), 6.66 (d,7 Hz,1H), 6.81 (d,8 Hz,1H), 6.94 (t,8 Hz,1H), 7.18 (m,1H), 7.71 (br s,1H). FAB-MS: calculated for C20H28FN3O4 393; found 394 (M+H,26%).

Sources & evidence

ORD record
ord-7b22efc9259b48839f06ad97fc1072d0
Source dataset
uspto-grants-1993_04
Patent number
US05206235

Reaction notes

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