HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → 3-t-Butoxycarbonylamino-3-methyl-N-[3,4-dihydro-3-oxo-2H-1,4-benzothiazin-2-yl]-butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid | HCID 10376046 | — |
| Reactant | 2-Amino-3,4-dihydro-3-oxo-2H-1,4-benzothiazine | HCID 10797452 | — |
| Product | 3-t-Butoxycarbonylamino-3-methyl-N-[3,4-dihydro-3-oxo-2H-1,4-benzothiazin-2-yl]-butanamide | HCID 19025720 | — |
Reaction Steps
Prepared from 2-amino-3,4-dihydro-3-oxo-2H-1,4-benzothiazine (Step A) and 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CD3OD): 1.26 (s,6H), 1.36 (s,9H), 2.47 (d,13 Hz,1H), 2.57 (d,13 Hz,1H), 5.52 (br s,1H), 6.31 (br s,1H), 7.00 (m,2H), 7.22 (m,2H). FAB-MS: calculated for C18H25N3O4S 379; found 380 (M+H,26%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206235 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-73ccafd2fc184017bf22bded6c913327 |
| Source note | uspto-grants-1993_04 |