HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromopropyl)benzene → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[3-phenylpropyl]-1H-1-benzazepin-3-yl]-butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromopropyl)benzene | HCID 12503 | — |
| Reactant | 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide | HCID 21836609 | — |
| Product | 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[3-phenylpropyl]-1H-1-benzazepin-3-yl]-butanamide | HCID 19766175 | — |
Reaction Steps
Prepared from 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide (Example 51, Step A) and 3-phenylpropyl bromide by the procedure described in Example 3, Step A. 1H NMR (200 MHz, CDCl3): 1.38 (s,6H), 1.82 (m,4H), 2.4-2.9 (m,7H), 3.45 (m,1H), 4.36 (m,1H), 5.02 (s,2H), 5.64 (s,1H), 6.69 (d,8 Hz,1H), 6.9-7.4 (m,14H). FAB-MS: calculated for C32H37N3O4 527; found 528 (M+H,100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206235 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-fc95823f4ca54f64a3080a2cddaabdde |
| Source note | uspto-grants-1993_04 |