反应详情

21 g (200 mmol) of 4-methyl-3-thiosemicarbazide in 1000 mL of acetone was heated at reflux for 2 hours. To the solution was then added dropwise 20.4 g (220 mmol) of chloroacetone. The reaction mixture was heated at reflux for 7 hours and then concentrated. The resulting crude product was recrystallized from acetone. This gave 23 g of an orange powder (63% of the theoretical).

1. temperatureat reflux for 2 hours
2. temperatureThe reaction mixture was heated
3. temperatureat reflux for 7 hours
4. concentrationconcentrated
5. customThe resulting crude product was recrystallized from acetone