HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetone → 2-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Dimethyl acetylenedicarboxylate | HCID 12980 | — |
| Reactant | Sodium hydrosulfide | HCID 28015 | — |
| Product | 2-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester | HCID 10608080 | — |
Reaction Steps
According to the description in Synth. Commun., 1996, 26, 1083, methyl 2-acetyl-3-hydroxythiophene-5-carboxylate was synthesized with chloroacetone, dimethyl acetylene dicarboxylate and sodium hydrosulfide as starting materials (yield: 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291449B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-ecc73145941641afa70ccfc6f141ecaa |
| Source note | uspto-grants-2007_11 |