HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Acetyl-3-hydroxythiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester | HCID 10608080 | — |
| Catalyst | Copper quinoline | HCID 67118996 | — |
| Product | 2-Acetyl-3-hydroxythiophene | HCID 13352352 | 58% |
Reaction Steps
The above-obtained methyl 2-acetyl-3-hydroxythiophene-5-carboxylate was hydrolyzed with an aqueous solution of sodium hydroxide, the hydrolyzate was heated with copper-quinoline to be decarboxylated, thereby the objective 2-acetyl-3-hydroxythiophene was obtained (yield: 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291449B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-a347ccf5ee2649d3adda0b8311740e3e |
| Source note | uspto-grants-2007_11 |