HCID 67132057, compound → HCID 67132009, compound

HRID 1591654Notes

Reaction equation

HRID 1591654 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][CH:27]=2)[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[C:32]([C:29]1[CH:28]=[CH:27][C:26]([O:25][CH2:24][CH2:23][CH2:22][N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:31][CH:30]=1)#[N:33]

Participants

4

Reactant 1

HCID 67132057HCID 67132057, compound

Product 1

HCID 67132009HCID 67132009, compoundYield 84.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.56 g of tert-butyl 1-benzyl-4-piperidinyl[3-(4-cyanophenoxy)propyl]carbamate was dissolved in 20 ml of methanol, and then, 0.30 g of 5% palladium-carbon was added to the solution, followed by stirring under a hydrogen atmosphere at room temperature under an atmospheric pressure for 18 hours. After completion of the reaction, the catalyst was removed, and the solvent was then removed under a reduced pressure to obtain 1.05 g of tert-butyl 3-(4-cyanophenoxy)propyl(4-piperidinyl)carbamate.

Workup

  1. customAfter completion of the reaction
  2. customthe catalyst was removed
  3. customthe solvent was then removed under a reduced pressure

Sources & evidence

ORD record
ord-24f2856a70854a2898a5b7b103ad6c70
Source dataset
uspto-grants-2007_11
Patent number
US07291617B2

Reaction notes

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