Diphosgene → HCID 21956014, compound

HRID 1591661Notes

Reaction equation

HRID 1591661 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH2:6][NH:7][CH3:8].ClC([O:17][C:18]([Cl:21])(Cl)Cl)=O>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH2:6][N:7]([CH3:8])[C:18]([Cl:21])=[O:17]

Participants

4

Reactant 2

HCID 10426DiphosgeneHCID 592161(3,4-Dimethoxybenzyl)methylamine

Product 1

HCID 21956014HCID 21956014, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.00 g (5.52 mmol) of 3,4-dimethoxybenzyl-N-methylamine (obtainable by reductive amination from 3,4-dimethoxybenzaldehyde) are dissolved in 20 ml of anhydrous pyridine. 0.60 g (0.37 mmol, 3.04 mmol) of trichloromethyl chloroformate (“diphosgene”) is added, and the mixture is left to stir at room temperature overnight. The solution is employed without workup directly in the next stage.

Workup

  1. waitthe mixture is left

Sources & evidence

ORD record
ord-ab297d11bbaf462ea61f9f69a82e5f18
Source dataset
uspto-grants-2007_11
Patent number
US07291622B2

Reaction notes

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