Trifluoromethanesulfonic acid → HCID 20760424, compound

HRID 1591679Notes

Reaction equation

HRID 1591679 reaction equation
[F:1][C:2]([F:8])([F:7])[S:3]([OH:6])(=[O:5])=[O:4].[CH2:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[N:18]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[F:39])[C:19]([C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1O)=[O:20]>N1C=CC=CC=1>[CH2:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[N:18]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[F:39])[C:19]([C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1[O:4][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:6])=[O:5])=[O:20]

Participants

4

Reactant 2

HCID 62406Trifluoromethanesulfonic acidHCID 22567001HCID 22567001, compound

Product 1

HCID 20760424HCID 20760424, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Trifluoromethanesulfonic acid anhydrous (0.27 mL, 1.6 mmol) is added dropwise in 10 minutes to a solution of 2-hydroxy-naphthalene-1-carboxylic acid indan-2-yl-(2-fluoro-benzyl)-amide (17) (323 mg, 0.8 mmol) in anhydrous pyridine (5 mL) at 0° C. under nitrogen. The mixture is stirred at room temperature overnight and concentrated under reduced pressure. The residue (18) is dried in vacuo and used for the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dry with materialThe residue (18) is dried in vacuo
  3. customused for the next step without further purification

Sources & evidence

ORD record
ord-a0e42e9f5c5c4120ba5202278cf0753e
Source dataset
uspto-grants-2007_11
Patent number
US07291621B2

Reaction notes

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