反应详情

To a solution of 42.26 g (244 mmol) of 4-[1,2,3]-triazol-2-yl-benzaldehyde in 140 ml of THF and 420 ml of MeOH, 9.23 g (244 mmol) of NaBH4 are added portionwise at 0-5° C. and the mixture is stirred for 30 min. at the same temperature. The reaction is quenched with sat. NH4Cl at 0-5° C. and the mixture is extracted with AcOEt. The combined extracts are washed with brine, dried over MgSO4 and concentrated under reduced pressure to give the title compound as a colorless solid.

1. customThe reaction is quenched with sat. NH4Cl at 0-5° C.
2. extractionthe mixture is extracted with AcOEt
3. washThe combined extracts are washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated under reduced pressure