Ethylenediamine → HCID 69239199, compound

HRID 1591764Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][C:12](=[O:29])[CH2:13][CH2:14][CH2:15][NH:16][CH2:17][S:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=2[Cl:28])(=[O:20])=[O:19])=[CH:5][CH:4]=1)#[N:2].[S].[CH2:31](N)[CH2:32][NH2:33]>>[Cl:28][C:22]1[C:23]([Cl:27])=[CH:24][CH:25]=[CH:26][C:21]=1[S:18]([CH2:17][NH:16][CH2:15][CH2:14][CH2:13][C:12]([NH:11][CH2:10][CH2:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]2[NH:33][CH2:32][CH2:31][N:2]=2)=[CH:8][CH:7]=1)=[O:29])(=[O:20])=[O:19]

Participants

Reactant 3

HCID 3301Ethylenediamine

HCID 5362487Sulfur

HCID 69423665HCID 69423665, compound

Product 1

HCID 69239199HCID 69239199, compound

Procedure

Analogously to 13b), 4-[(2,3-dichlorobenzenesulphonyl)methylamino]-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}butyramide was prepared from 0.297 g (0.654 mmol) of N-[2-(4-cyanophenyl)ethyl]4-[(2,3-dichloro-benzenesulphonyl)methylamino]butyramide, 42 mg (1.31 mmol) of sulphur and 1.8 ml of ethylenediamine.

Sources & evidence

ORD record: ord-c0b826710a654424a0476236983b2492
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07291642B2

Reaction notes

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