Formate → N-(2-Fluorophenyl)formamide

Participants

Reaction Steps

Under argon gas, formate (6.1 mL) was added to acetic anhydride (15.5 mL) at 0□ and the mixture was stirred at 50□ for 2 hours. The reaction mixture was cooled to room temperature and diluted with tetrahydrofuran (10 mL). Tetrahydrofuran (20 mL) solution containing 2-fluoroaniline (5.56 g) was added into the diluent at room temperature and stirred at room temperature for 1 hour. A title compound having the following physical properties was obtained by concentrating the reaction mixture. The obtained title compound was used for the following reaction without further purification.

Provenance & Evidence