Formate → N-(2-Fluorophenyl)formamide

HRID 1591767Notes

Reaction equation

HRID 1591767 reaction equation
[CH:1]([O-:3])=O.C(OC(=O)C)(=O)C.[F:11][C:12]1[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14]>O1CCCC1>[CH:1]([NH:14][C:13]1[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=1[F:11])=[O:3]

Participants

5

Reactant 3

HCID 283FormateHCID 7918Acetic AnhydrideHCID 95842-Fluoroaniline

Product 1

HCID 12803459N-(2-Fluorophenyl)formamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Under argon gas, formate (6.1 mL) was added to acetic anhydride (15.5 mL) at 0□ and the mixture was stirred at 50□ for 2 hours. The reaction mixture was cooled to room temperature and diluted with tetrahydrofuran (10 mL). Tetrahydrofuran (20 mL) solution containing 2-fluoroaniline (5.56 g) was added into the diluent at room temperature and stirred at room temperature for 1 hour. A title compound having the following physical properties was obtained by concentrating the reaction mixture. The obtained title compound was used for the following reaction without further purification.

Workup

  1. additionwas added into the diluent at room temperature
  2. stirringstirred at room temperature for 1 hour

Sources & evidence

ORD record
ord-feac9e7332c94954a7e5e98c1e1bd4cc
Source dataset
uspto-grants-2007_11
Patent number
US07291644B2

Reaction notes

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