4-(Propan-2-yl)benzene-1-sulfonyl chloride → N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]4-isopropylbenzenesulfonamide

HRID 1591814Notes

Reaction equation

HRID 1591814 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH:16]([C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1)([CH3:18])[CH3:17]>>[C:14]([C:11]1[N:12]([CH3:13])[C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:25]([C:22]3[CH:23]=[CH:24][C:19]([CH:16]([CH3:18])[CH3:17])=[CH:20][CH:21]=3)(=[O:27])=[O:26])=[CH:3][CH:4]=2)=[CH:9][CH:10]=1)#[N:15]

Participants

3

Reactant 2

HCID 27348824-(Propan-2-yl)benzene-1-sulfonyl chlorideHCID 160504305-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carbonitrile

Product 1

HCID 16050905N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]4-isopropylbenzenesulfonamide

Procedure

The title compound was prepared according to general procedure for sulfonylation of 5-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carbonitrile using 4-isopropyl-benzenesulfonyl chloride (120 mg, 0.55 mmol) to provide N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]4-isopropylbenzenesulfonamide (0.049 g).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-8884d75b57874ca08ead91c823e2cc3d
Source dataset
uspto-grants-2007_11
Patent number
US07291643B2

Reaction notes

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