反应详情

温度

170 °C

Tert-butyl-2-cyano-5-{4-{(ethylsulfonyl)amino]phenyl}-1H-pyrrole-1-carboxylate (2.3 g, 6.1 mmol) was dissolved in dimethylacetamide (60 mL) and heated to 170° C. for 30 minutes. The mixture was cooled and partitioned between water and ethyl acetate. The organic layers were dried over magnesium sulfate, and concentrated. The residue was purified by silica gel Flash Chromatography (hexane/ethyl acetate; 1:1) to afford the title compound (1.51 g, 90%).

1. temperatureThe mixture was cooled
2. custompartitioned between water and ethyl acetate
3. dry with materialThe organic layers were dried over magnesium sulfate
4. concentrationconcentrated
5. customThe residue was purified by silica gel Flash Chromatography (hexane/ethyl acetate; 1:1)