反应详情

温度

50 °C

A mixture of methanesulfonyl chloride (0.046 mL, 0.66 mmol) and 5-(4-amino-2,6-difluorophenyl)-1-methyl-1H-pyrrole-2-carbonitrile (0.100 g, 0.429 mmol) in pyridine (1.5 mL) was heated to 50° C. for 4 hours. The reaction mixture was acidified with 1N HCl solution and extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (dichloromethane/acetone, 97/3) to afford the title compound (0.060 g, 45%).

1. extractionextracted with ethyl acetate
2. dry with materialThe combined organic layers were dried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified by silica gel column chromatography (dichloromethane/acetone, 97/3)