Sodium Hydroxide → HCID 131726666, compound

HRID 1591936Notes

Reaction equation

HRID 1591936 reaction equation
[OH-].[Na+:2].[F:3][C:4]([F:42])([F:41])[C:5]1[CH:6]=[C:7]([S:15]([NH:18][C:19]2[S:20][C:21]3[CH2:22][N:23]([C:28]4[CH:36]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:34]=[CH:33][C:29]=4[C:30]([NH2:32])=[O:31])[CH2:24][CH2:25][C:26]=3[N:27]=2)(=[O:17])=[O:16])[CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1>CCO>[Na+:2].[F:42][C:4]([F:3])([F:41])[C:5]1[CH:6]=[C:7]([S:15]([NH:18][C:19]2[S:20][C:21]3[CH2:22][N:23]([C:28]4[CH:36]=[C:35]([C:37]([F:38])([F:39])[F:40])[CH:34]=[CH:33][C:29]=4[C:30]([NH-:32])=[O:31])[CH2:24][CH2:25][C:26]=3[N:27]=2)(=[O:16])=[O:17])[CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 99389462-[2-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-6,7-dihydro-4H-thiazolo-[5,4-c]pyridin-5-yl]-4-trifluoromethyl-benzamide

Product 1

HCID 131726666HCID 131726666, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.9 ml of an aqueous 0.1 M NaOH solution are added to a solution of 118 mg of 2-[2-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7-dihydro-4H-thiazolo-[5,4-c]pyridin-5-yl]-4-trifluoromethyl-benzamide in 10 ml of EtOH, and the mixture obtained is stirred at RT for 5 minutes. From the mixture obtained solvent is evaporated and the evaporation residue obtained is subjected to lyophilisation. [2-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-6,7-dihydro-4H-thiazolo-[5,4-c]pyridin-5-yl]-4-trifluoromethyl-benzamide sodium salt is obtained.

Workup

  1. customthe mixture obtained
  2. customFrom the mixture obtained solvent
  3. customis evaporated
  4. customthe evaporation residue obtained

Sources & evidence

ORD record
ord-b12f891470e4489982346a243b610541
Source dataset
uspto-grants-2007_11
Patent number
US07291734B2

Reaction notes

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