反应详情

A mixture of tert-butyl 9-nitro-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate (0.25 g, 0.75 mmol), zinc (1.48 g, 22.6 mmol) and calcium chloride (0.04 g, 0.38 mmol) in 78% ethanol (7.5 mL) was refluxed for 2 h and filtered hot. The filtrate was concentrated in vacuo to dryness to give 0.22 g (99%) of solid as the desired product: MS (EI) m/z 302 (MH+).

1. temperaturewas refluxed for 2 h
2. filtrationfiltered hot
3. concentrationThe filtrate was concentrated in vacuo to dryness