n-[1-(4-Amino-9-trifluoromethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-7-yl)-piperidin-4-yl]-formamide → HCID 11152842, compound

Participants

Reaction Conditions

Reaction Steps

The above yellow formamide (268 mg, 0.676 mmol) was dissolved in 3 mL of 6% HCl. This solution was heated at 80° C. for 40 min. The reaction mixture was diluted with water and neutralized with sodium carbonate to pH 10. The resulting solid was collected by filtration and recrystallized from MeOH to give the title compound as a white crystalline product (171 mg, 69%).

Provenance & Evidence