HCID 11463597, compound → HCID 11152842, compound

HRID 1592072Notes

Reaction equation

HRID 1592072 reaction equation
[NH2:1][C:2]1[C:3]2[S:10][C:9]3[N:11]=[C:12]([N:19]4[CH2:24][CH2:23][CH:22]([NH:25]C=O)[CH2:21][CH2:20]4)[CH:13]=[C:14]([C:15]([F:18])([F:17])[F:16])[C:8]=3[C:4]=2[N:5]=[CH:6][N:7]=1>Cl.O.C(=O)([O-])[O-].[Na+].[Na+]>[NH2:25][CH:22]1[CH2:23][CH2:24][N:19]([C:12]2[CH:13]=[C:14]([C:15]([F:16])([F:18])[F:17])[C:8]3[C:4]4[N:5]=[CH:6][N:7]=[C:2]([NH2:1])[C:3]=4[S:10][C:9]=3[N:11]=2)[CH2:20][CH2:21]1

Participants

5

Reactant 1

HCID 11463597HCID 11463597, compound

Product 1

HCID 11152842HCID 11152842, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 962WaterSolventHCID 10340Sodium CarbonateSolvent

Conditions

Temperature
80 °C

Procedure

The above yellow formamide (268 mg, 0.676 mmol) was dissolved in 3 mL of 6% HCl. This solution was heated at 80° C. for 40 min. The reaction mixture was diluted with water and neutralized with sodium carbonate to pH 10. The resulting solid was collected by filtration and recrystallized from MeOH to give the title compound as a white crystalline product (171 mg, 69%).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customrecrystallized from MeOH

Sources & evidence

ORD record
ord-40fa61b0bce0439581fef4f421618ee1
Source dataset
uspto-grants-2007_11
Patent number
US07291733B2

Reaction notes

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