HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Azidopropyl)-4-fluorobenzene → 3-(4-Fluorophenyl)propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Azidopropyl)-4-fluorobenzene | HCID 58997701 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Fluorophenyl)propan-1-amine | HCID 6483796 | 57.1% |
Reaction Steps
The product from step e (0.79 g, 6.4 mmol) was dissolved in 100 mL of MeOH and added carefully to 0.20 g of 10% Pd/C under N2. The mixture was hydrogenated in a Parr shaker at 50 PSI overnight. Filtration through fiberglass filter paper under N2 and under vacuum yielded 0.56 g of a clear colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291744B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-e98aa9fc6dbc41d6b7b745af3d109ccc |
| Source note | uspto-grants-2007_11 |