HCID 58997692, compound → HCID 58997640, compound

HRID 1592322Notes

Reaction equation

HRID 1592322 reaction equation
C(OC(=O)[NH:10][C@@H:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:17][N:18]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)C1C=CC=CC=1>CO.[Pd]>[C:32]([O:31][C:29]([N:18]([CH2:17][C@@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:11]1[NH2:10])[CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:30])([CH3:35])([CH3:33])[CH3:34]

Participants

4

Reactant 1

HCID 58997692HCID 58997692, compound

Product 1

HCID 58997640HCID 58997640, compoundYield 65%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The product from Step h (0.7 g, 1.9 mmol) was dissolved in 100 mL MeOH and added carefully to 0.1 g of 10% Pd/C under N2. The mixture was hydrogenated in a Parr shaker at 50 PSI overnight. Filtration through fiberglass filter paper under N2 and under vacuum yielded 0.45 g of a clear colorless oil.

Workup

  1. customwas hydrogenated in a Parr shaker at 50 PSI overnight
  2. filtrationFiltration through fiberglass
  3. filtrationfilter paper under N2

Sources & evidence

ORD record
ord-380fd544fa844d5eab3d21cc505b0592
Source dataset
uspto-grants-2007_11
Patent number
US07291744B2

Reaction notes

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