反应详情

The crude amide was dissolved in ether and cooled in an ice bath and treated with LAH (1.35 g, 35 mmol) and stirred for 1 hour. The reaction was quenched with 1 N HCl, extracted with ethyl acetate and washed successively with water and brine, dried over MgSO4. The extract was filtered and evaporated under vacuum to give 4.3 g of 3-(4-fluorophenyl)propanal.

1. temperaturecooled in an ice bath
2. customThe reaction was quenched with 1 N HCl
3. extractionextracted with ethyl acetate
4. washwashed successively with water and brine
5. dry with materialdried over MgSO4
6. filtrationThe extract was filtered
7. customevaporated under vacuum