HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 3-(4-Fluorophenyl)propanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | N-Methoxy-N-methyl-4-fluoro-benzenepropanamide | HCID 22612404 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-(4-Fluorophenyl)propanal | HCID 10197782 | — |
Reaction Steps
The crude amide was dissolved in ether and cooled in an ice bath and treated with LAH (1.35 g, 35 mmol) and stirred for 1 hour. The reaction was quenched with 1 N HCl, extracted with ethyl acetate and washed successively with water and brine, dried over MgSO4. The extract was filtered and evaporated under vacuum to give 4.3 g of 3-(4-fluorophenyl)propanal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291744B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-8fc62ebd43a44bc299c210eec26b1a11 |
| Source note | uspto-grants-2007_11 |