HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylpyridine-2-carboxaldehyde → {3-[(3-Methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-propyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylpyridine-2-carboxaldehyde | HCID 1501874 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | [3-(1-Pyridin-2-yl-ethylamino)-propyl]-carbamic acid tert-butyl ester | HCID 67272175 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | {3-[(3-Methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-propyl}-carbamic acid tert-butyl ester | HCID 67273022 | — |
Reaction Steps
Using General Procedure B: Reaction of [3-(1-pyridin-2-yl-ethylamino)-propyl]-carbamic acid tert-butyl ester and 3-methyl-pyridine-2-carboxaldehyde with NaBH(OAc)3 in CH2Cl2 gave {3-[(3-methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-propyl}-carbamic acid tert-butyl ester as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291631B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-1e9b01a64939466b9f7f34d29ac1df9c |
| Source note | uspto-grants-2007_11 |