HRID1592563

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]

HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

HCID18731683

3,5-Dimethylpyridine-2-carbaldehyde

C8H9NO

反应SMILES：CC(C)(C)OC(=O)N1CCC(NCc2ncccc2-c2ccccc2)CC1

HCID67273605

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1cnc(CN(Cc2ncccc2-c2ccccc2)C2CCN(C(=O)OC(C)(C)C)CC2)c(C)c1

HCID67273310

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Using General Procedure B: Reaction of the amine from above and 3,5-dimethyl-2-pyridinecarboxaldehyde in CH2Cl2 with NaBH(OAc)3 gave 4-[(3,5-dimethyl-pyridin-2-ylmethyl)-(3-phenyl-pyridin-2-ylmethyl)amino]-piperidine-1-carboxylic acid tert-butyl ester.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6368dfc4e8354696bccae450a6af76b1
来源数据集: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07291631B2
来源说明: uspto-grants-2007_11

反应SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:28][C:29]1[C:30]([CH:36]=O)=[N:31][CH:32]=[C:33]([CH3:35])[CH:34]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:36][C:30]2[C:29]([CH3:28])=[CH:34][C:33]([CH3:35])=[CH:32][N:31]=2)[CH2:15][C:16]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]