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1-(Pyridin-2-yl)ethan-1-amine → (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Pyridin-2-yl)ethan-1-amine | HCID 541877 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 1-(2-Trimethylsilylethoxymethyl)-2-formyl-benzimidazole | HCID 12017128 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine | HCID 67272285 | — |
反応手順
Using General Procedure B: Reaction of 1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazole-2-carbaldehyde in CH2Cl2 with 1-pyridin-2-yl-ethylamine and NaBH(OAc)3 gave (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine as a pale green oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07291631B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-f2ca935518664d10a906b0b374342d13 |
| 出典メモ | uspto-grants-2007_11 |