1H-Tetrazole, 1-methyl- → HCID 69409082, compound

HRID 1592761Notes

Reaction equation

HRID 1592761 reaction equation
[CH3:1][N:2]1[CH:6]=[N:5]N=[N:3]1.[CH2:7]([Li])CCC.[C:12]([N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH:31]=O)[CH2:21][CH2:20]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[C:12]([N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH2:31][C:6]2[N:2]([CH3:1])[N:3]=[CH:7][N:5]=2)[CH2:21][CH2:20]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]

Participants

4

Reactant 3

HCID 1401231H-Tetrazole, 1-methyl-HCID 64909901-Boc-4-(2-formylphenyl)piperazineHCID 178418339Butyllithium

Product 1

HCID 69409082HCID 69409082, compound

Procedure

1-methyltetrazole was lithiated with n-butyllithium and reacted with N-Boc-4-(2-formylphenyl)-piperazine in a manner similar to preparation 113A. The resulting alcohol was deoxygenated in a manner similar to preparation 115A to afford the final compound. LRMS (ESI+): 358.3 (M+1)

Workup

  1. customThe resulting alcohol was deoxygenated in a manner similar to preparation 115A

Sources & evidence

ORD record
ord-6e26a5557556495a91f087605939faac
Source dataset
uspto-grants-2007_11
Patent number
US07291619B2

Reaction notes

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